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KMID : 1034320120030010015
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Sleep Medicine Research
2012 Volume.3 No. 1 p.15 ~ p.19
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Comparison of Anti-Streptococcal Antibodies in Patients with Narcolepsy and Control Group
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Kim Tae-Won
Kang Dong-Woo
Kim Soo-Young
Han Jin-Hee
Lee Sung-Pil
Hong Seung-Chul
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Abstract
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Background and Objective It has been reported that Streptococcal infection is probably a significant environmental trigger for narcolepsy patients from recent studies. However the relationship between the streptococcal infection and narcolepsy is not clear. The aim of this study is to explore the anti-streptolysin O (ASO) titer in narcolepsy patients and healthy control, and the associations of ASO titer levels and polysomnographic findings.
Methods: Sixty two narcolepsy patients and Fifty six healthy controls were recruited at the Sleep Center of St. Vincent’s Hospital. The multiple sleep latency test data and polysomnographic findings from the time of their diagnosis were reviewed. Disease duration was defined as the time between the first symptom and time of blood draw. HLA typing was also performed. Participants were tested for markers of immune response to β hemolytic streptococcus.
Results: Results indicated that titers of anti-streptococcal antibodies were not significantly different between patients with narcolepsy and healthy controls. There was no significant difference of ASO titer between the HLA DQB1*0602 positive group and HLA DQB1*0602 negative group. In narcolepsy with cataplexy patients, rapid eye movement sleep latency was significantly shorter in the ASO > 200 group.
Conclusions: There is no significant difference of ASO titers between patients with narcolepsy and healthy controls. The association between streptococcal infections and narcolepsy in Asian people may be not as significant as Caucasian people.
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KEYWORD
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Narcolepsy, Cataplexy, Anti-streptolysin O
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